Concurrent fMRI, [11C]raclopride-PET and deep brain stimulation of the ventral tegmental area
Christin Y. Sander1, John Arsenault2, Bruce R. Rosen1, Joseph B Mandeville1, and Wim Vanduffel1
1Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Radiology, Massachusetts General Hospital, Charlestown, MA, United States
Deep brain
stimulation (DBS) through implantable neurostimulation electrodes that affect
dopaminergic control is an important symptomatic therapy in movement disorders,
and has been shown to affect reinforcement learning and motivation. In this study, we employ concurrent DBS in the ventral tegemental area during simultaneous PET/fMRI to understand dopaminergic signature of DBS.
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