An
emerging method for quantitative mapping of OEF is by dual calibration of the
BOLD signal. 1,2 However, this method is highly sensitive to
measurement noise, resulting in unstable estimates of OEF. An
alternative approach is to use flow-diffusion equations to calculate the
biophysically supported OEF. 3 However, this approach is limited by
the need to assume a tissue oxygen tension (PtO2). We propose a
method for combining these two approaches, producing calibrated BOLD estimates
of OEF that are constrained by a modelled flow-diffusion relationship of oxygen
extraction. The proposed method is shown to produce stable estimates of OEF and
PtO2.
