Abstract #1708

Intrinsic functional connectivity in patients with presbycusis

Fei Gao¹, Guangbin Wang¹, Bin Zhao¹, Muwei Li², Fuxin Ren¹, and Weibo Chen³

¹Shandong Medical Imaging Research Institute, Shandong University, JINAN, China, People's Republic of, ²College of Electronics and Information Engineering, Sichuan University, Chengdu, China, People's Republic of, ³Philips Healthcare, Shanghai, China, People's Republic of

Presbycusis is the most common sensory deficit in the ageing population. However, little is known about whether the topological properties of brain functional networks is disrupted in patients with presbycusis. Our study demonstrates decreased clustering coefficient, local efficiency and strength in the primary auditory cortex in patients with presbycusis, as compared to age- and gender-matched healthy controls. Our study provides evidence of presbycusis-related disruptions in brain functional networks in patients with presbycusis. It is believed that our findings could be important for exploring functional changes in the central presbycusis.

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