Our results suggest an association of abnormal regional
function in the putamen and prefrontal cortex and hyperconnectivity between
them with AVHs in SZ. The functional interaction of the putamen with DLPFC
and Broca’s area seems to be crucial for AVHs in SZ. Additionally, the putamen-related regional
and network functional deficits may also serve as a potential diagnostic biomarker
of AVHs in SZ based on the direct evidence in vivo we
found. In SZ patients, there
is an extensive hypoconnectivity within cortical-striatal-cerebellar networks,
which further supports the current thinking about disconnection hypothesis of SZ.
