Jun Zhao1, Chuan-Ming Li1, Xin Wei1, and Jian Wang1
This study aimed to investigate any cerebral function deficits in AS(Ankylosing spondylitis) using functional MRI technology and its possible relationship to clinical and laboratory results. Compared with normal controls, AS patients showed widespread brain activity and connectivity alterations. Functional connectivity strength of the left precuneus and the left middle temporal gyrus were closely correlated with the the BASDAI scores, ESR and hsCRP in AS patients. AS is associated with a altered cortical activity of rs-fMRI signals. Measurement of functional connectivity strength of the left precuneus and the left middle temporal gyrus may aid in the clinical detection and evaluation of AS
