Drug abuse has detrimental effects
on the brain function, which lead to drug use disorders. In vivo non-invasive biomarkers are needed to determine the neurobiological
outcomes of addictive drugs on the brain. Functional MRI and graph theory offer
an analytical approach to address brain network changes associated with
psychiatric disorders. In the present study we determined the effects of two
addictive psychostimulant drugs. Comparison between
saline and drug administered shows a reduction in the connectivity at 1 hr but
not at 24 hrs. Acute
administration of the two psychostimulants studied produce only transient
effects lasting at least 1 hr.
