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Abstract #1683

Quasi-periodic pattern of fMRI contributes to functional connectivity and explores difference between Major Depressive Disorder and control

Kai Wang1, Waqas Majeed2, Garth Thompson3, Kui Ying4, Yan Zhu5, and Shella Keilholz6

1Department of Biomedical Engineering, Tsinghua University, Beijing, China, People's Republic of, 2Department of Electrical Engineering, LUMS School of Science and Engineering, Lahore, Pakistan, 3Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 4Department of Engineering Physics, Tsinghua University, Beijing, China, People's Republic of, 5Psychiatry Department, Yu Quan Hospital, Tsinghua University, Beijing, China, People's Republic of, 6Department of Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, GA, United States

Quasiperiodic pattersn (QPPs) of BOLD fluctuations, first reported in [1,2] are likely contributors to functional connectivity (FC) due to their spatial and temporal structure. FC has been widely used to explore the altered brain organization in patients suffering from psychological disorders like Major Depressive Disorder (MDD). In this project, we examined the contribution of QPPs to FC in both normal subjects and MDD patients. Results showed that QPPs are a major contributor to FC, and that QPP abnormality can be a contributor to or marker of psychiatric or neurological disorders.

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