Abstract #1665

Investigating the neural substrates of verbal working memory in children with dyslexia: An effective connectivity study

Fu Yu Kwok¹, Beth Ann O'Brien², Kiat Hong Stacey Tay³, and SH Annabel Chen^1,4

¹Division of Psychology, Nanyang Technological University, Singapore, Singapore, ²National Institute of Education, Nanyang Technological University, Singapore, Singapore, ³Paediatric Neurology and Developmental Paediatrics, National University Hospital, National University of Singapore, Singapore, Singapore, ⁴Centre for Research And Development Learning, Nanyang Technological University, Singapore, Singapore

Dynamic causal modeling was utilized to examine the effective connectivity during verbal working memory in children with dyslexia and typically developing children. Seven regions of interest—FG, IFG, IOG, IPL, thalamus, inferior cerebellum and superior cerebellum were included into the analyses. Results indicated that the effect of dyslexia led to shift in effective network connectivity. The present study furthered our understanding of the cerebro-cerebellar effective network connectivity in both children with dyslexia and typically developing children. In addition, it provided new insights about the effects of dyslexia on this network.

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