Condition effects on resting-state CBF reproducibility and reliability
Marta Vidorreta1,2, Natalie N Katchmar3, Daniel H Wolf3, and John A Detre1,2
1Neurology, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Psychiatry, University of Pennsylvania, Philadelphia, PA, United States
Cerebral blood flow (CBF) data were collected with arterial
spin labeled (ASL) perfusion MRI in a group of young, healthy subjects over two
sessions, scheduled a week apart. CBF and functional connectivity metrics were derived
from the CBF time series across four different resting conditions: ‘eyes open’,
‘eyes closed’, ‘fixation’ (eyes fixated on a cross), and ‘PVT’ (low-frequency
psychomotor vigilance task). Absolute
CBF was highly reproducible both within and across sessions. Results suggest
that ‘fixation’ is inferior to the other conditions tested for resting-state ASL
reproducibility.
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