Abstract #1656

Exploring Resting-State Functional Connectivity Invariants across the Life Span using a Novel Graph Model

Ottavia Dipasquale^1,2, Paolo Finotelli³, Isa Costantini¹, Giuseppe Baselli¹, Francesca Baglio², Paolo Dulio³, and Mara Cercignani⁴

¹Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy, ²IRCCS, Don Gnocchi Foundation, Milan, Italy, ³Department of Mathematics "F. Brioschi", Politecnico di Milano, Milan, Italy, ⁴Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom

In this work we investigated resting-state functional connectivity (FC) changes and invariant properties in 133 healthy people across the life-span (6-79y) using a novel graph model that emphasizes centrality of nodes. This model estimates a weight for each node’s pair (94 cortical regions) accounting for the node degrees, anatomical distance and FC between them and penalizing the formation of long connections. Preliminary findings in two groups of 25 and 62 year-old subjects highlighted a number of interesting properties and confirmed the important role of the Precuneus and the Cingulate Gyrus, which are characterized by high functional strength and degree.

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