It has been reported that end-stage renal
disease (ESRD) patients have cognitive decline in all aspects, especially in
attention and executive function, and this is lack of objective noninvasive modalities
to monitor the cognition impairment by now. Resting-stage functional MR which
can detect the change of brain function as a newly-developing imaging method
has been widely used to evaluate the cognitive status in many diseases. Our findings
show the aberrant functional connectivity of frontal-parietal network (FPN) in
ESRD patients, and supported by the results of neuropsychological tests. FPN
functional connectivity may serve as a biomarker to monitor the attention and
executive function impairment in patients with ESRD in the future.
