Abstract #1610

Quantitative Aerosol Deposition in Mechanically-Ventilated Healthy and Asthmatic Rats using UTE-MRI

Hongchen Wang¹, Georges Willoquet¹, Catherine Sebrié¹, Sébastien Judé², Anne Maurin², Rose-Marie Dubuisson¹, Luc Darrasse¹, Geneviève Guillot¹, Ludovic de Rochefort¹, and Xavier Maître¹

¹Imagerie par Résonance Magnétique Médicale et Multi-Modalités (UMR8081) IR4M, CNRS, Univ. Paris-Sud, Orsay, France, ²Centre de Recherches Biologiques, CERB, Baugy, France

Asthma is the most common chronic respiratory disease treated with inhaled therapy. However, aerosol deposition patterns are complex and imaging methods are needed to improve delivery efficiency. 3D UTE-MRI combined with aerosolized Gd-DOTA had been formerly applied onto spontaneous nose-only-breathing animals. Here, a mechanical administration system was developed to ventilate and nebulize rats. Resulting aerosol distribution and kinetics were compared with free-breathing in healthy and asthmatic animals.

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