Abstract #1585

The effect of hyperbaric oxygen therapy on healthy and diabetic rat kidneys measured with hyperpolarised [1-13C]pyruvate

Thomas Stokholm Nørlinger¹, Per Mose Nielsen¹, Emmeli Mikkelsen¹, Haiyun Qi¹, Kasper Hansen², Peter Kolstrup Agger³, Nikolaj Schmidt², Michael Pedersen², Hans Stødkilde-Jørgensen¹, Frederik Palm⁴, and Christoffer Laustsen¹

¹Department of Clinical Medicine, MR Research Centre, Aarhus, Denmark, ²Department of Clinical Medicine, Comparative Medicine Lab, Aarhus, Denmark, ³Dept. of Cardiothoracic and Vascular Surgery, Aarhus, Denmark, ⁴Department of Medical and Health Sciences, Division of Drug Research, Linköping, Sweden

Hyperbaric oxygen therapy (HBO) is a well-known adjuvant treatment for several medical conditions indicated by the Undersea and Hyperbaric Medical Society. It is generally well tolerated and the kidneys display no adverse side effects after HBO. In diabetes hypoxia has been shown to be an important contributing factor in the development of diabetic nephropathy. In this experiment we investigate whether HBO has a protective effect on the kidney by preventing metabolic derangement as a consequence of hypoxia in the diabetic kidneys.

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