Abstract #1538

Repeatability and sample size estimations for myelin water imaging

Thibo Billiet¹, Stefan Sunaert¹, Bea Van den Bergh¹, Ronald Peeters¹, Mathieu Vandenbulcke¹, and Louise Emsell¹

¹KU Leuven, Leuven, Belgium

Currently, only single slice repeatability results for myelin water imaging (MWI) metrics are available. We assessed the within- and between-subject variation of the myelin water fraction (MWF); intra- and extracellular water fraction (IEWF), and intra- and extracellular water geometric mean T2 time (IEW-gmT2) in a whole cerebrum MWI sequence¹ We demonstrated good within- and between subject variability, comparable to previous single-slice results. Future studies may benefit from sample size estimations documented in this work.

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