Abstract #1518

Enhanced sensitivity of renal pH measurement with MR-CEST ratiometric imaging of Iopamidol in a normal rodent model at 4.7 T

Yin Wu^1,2, Iris Yuwen Zhou¹, Takahiro Igarashi¹, Yingkun Guo¹, Lin Li¹, and Phillip Zhe Sun¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, People's Republic of

Renal pH was recently quantified with MR-CEST ratiometric imaging of Iopamidol at 7 T. However, the two exchangeable proton groups of Iopamidol would substantially overlap at lower magnetic field, leading to inaccurate pH quantification. Here, we investigated a Lorentzian-based decoupling algorithm to resolve the two saturation transfer effects for improved ratiometric pH measurement in rodents at 4.7 T. Results exhibits substantially enhanced range and sensitivity of pH measurements. The obtained renal pH maps are consistent with the published results. Therefore, the proposed method provides a novel way for reliable renal pH mapping, which benefits pH quantification at clinical field strengths.

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