Xiang Xu1,2, Kannie WY Chan1,2, Huanling Liu1,3, Yuguo Li1,2, Guanshu Liu1,2, Peter C.M. van Zijl1,2, and Jiadi Xu1,2
1Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Ultrasound, Guangzhou Panyu Central Hospital, Guangzhou, China, People's Republic of
An
on-resonance variable delay multi-pulse (onVDMP) CEST technique was developed for the detection of
fast-exchanging protons. The new method was applied to the detection of
glucoCEST signal changes upon venous glucose injection in a mouse tumor model
and compared with conventional cw-CEST method. Both methods highlight the tumor
and the blood vessels upon glucose injection in mice brain implanted with brain
tumors. However compared with cw-CEST, the onVDMP technique increased the tumor
contrast to noise ratio by about 50% due to its sensitivity to total fast exchanging
protons.
