Reproducibility and Variability of a Look-Locker FAIR ASL Sequence for Quantitative Measurement of Myocardial Blood Flow in Healthy Human Volunteers at 3T
Graeme A Keith1, Christopher T Rodgers1, Michael A Chappell2, and Matthew D Robson1
1Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 2Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
A previously presented arterial spin labelling
(ASL) method was tested for reproducibility and variability. These measures are
important to consider when planning a clinical study. The results presented
show that the method has the sensitivity required to detect changes in MBF in
pathology and under stress. The variation in individuals is shown to be less
than across the sample as a whole. This knowledge will be useful in the
planning of future clinical research studies.
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