Abstract #1463

3D Map of Perivascular Network in the Rat Brain

Magdoom Kulam¹, Alec Brown², Michael A King³, Thomas H Mareci^2,4,5, and Malisa Sarntinoranont^1,5

¹Department of Mechanical & Aerospace Engineering, University of Florida, Gainesville, FL, United States, ²Department of Physics, University of Florida, Gainesville, FL, United States, ³Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL, United States, ⁴Department of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL, United States, ⁵Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States

In the absence of lymphatic vessels in the brain, metabolic wastes were known to be cleared out of the brain along perivascular spaces which are annular gaps between blood vessels and the parenchyma. Abnormalities in the perivascular transport have been implicated in neurodegenerative disorders such as Alzheimer’s and syringomyelia. In this study, we have obtained a high resolution 3D reconstruction of the perivascular network in the rat brain for the first time. Combining the reconstructed vascular and perivascular networks using the current method with physical models may shed light into mechanisms underlying perivascular transport in normal and pathological states.

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