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Abstract #1460

In vivo longitudinal 1H MRS comparison of hippocampal and cerebellar changes due to Chronic Hepatic Encephalopathy, a rat model study

Veronika Rackayova1, Olivier Braissant2, Corina Berset3, Jocelyn Grosse4, Rolf Gruetter1,3, Valérie A. McLin5, and Cristina Cudalbu3

1Laboratory of Functional and Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, Lausanne, Switzerland, 2Service of Biomedicine, University Hospital of Lausanne, Lausanne, Vaud, Switzerland, Lausanne, Switzerland, 3Center for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, Lausanne, Switzerland, 4Laboratory of behavioral genetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, Lausanne, Switzerland, 5Swiss Center for Liver Disease in Children, Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland, Geneva, Switzerland

Chronic liver disease leads to Hepatic Encephalopathy - spectrum of neuropsychiatrical disorders. We investigated potential neurometabolic differences between two key brain regions (hippocampus and cerebellum). Cerebellum shows similar increase of glutamine but lower tNAA, Tau, Cr, Asc and different osmotic response indicating that these regions are influenced unequaly.

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