Wendy Ni1,2, Thomas Christen2, and Greg Zaharchuk2
1Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 2Department of Radiology, Stanford University, Stanford, CA, United States
The acetazolamide challenge can be used to assess cerebrovascular
reserve and oxygenation in patients with steno-occlusive diseases such Moyamoya,
thus enabling evaluation of the quantitative blood oxygen-level dependent
(qBOLD) approach of modeling tissue oxygenation. In this study, we mapped post-acetazolamide
oxygenation (with transverse relaxation rate R2’), CBF with arterial spin
labeling (ASL), and CBV with dynamic susceptibility contrast (DSC). We found that angiographically abnormal
tissues are relatively hypoperfused and hypoxic. Finally, we investigated a qBOLD biophysical
model for quantitative tissue oxygenation which suggested no difference in the
cerebral metabolic rate of oxygen consumption (CMRO2) between normal and
affected regions.
