1Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 2Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, 3Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, 4Translational Imaging Research Center, Taipei Medical University, Taipei, Taiwan, 5Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 6Division of Nephrology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 7Division of Nephrology, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 8Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States, 9Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States, 10Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC, United States, 11Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 12Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 13Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States