Abstract #1416

Arterial Spin Labeling Measured Choroidal Blood Flow is Reduced in Age-Related Macular Degeneration and Correlates with Severity Level

Weiying Dai^1,2, Lauren O’Loughlin¹, Gina Yu³, Li Zhao¹, David Alsop¹, and Jorge Arroyo³

¹Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States, ²Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ³Opthalmology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States

Age-related macular degeneration (AMD) has been associated with reduced choroidal blood flow. However, current methods do not provide spatial location of reduced choroidal blood flow. Here we explored the feasibility and capability of arterial spin labeling (ASL) magnetic resonance imaging (MRI) in observing reduced choroidal blood flow in AMD patients and the association with their severity levels. Choroidal blood flow was significantly reduced in patients with AMD compared to controls. Most importantly, choroidal blood flow was significantly correlated with the severity levels of AMD. This suggests that ASL may be a useful tool to study the role of choroidal blood flow in the pathogenesis of AMD.

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