Abstract #1403

Measuring Longitudinal Changes in Cerebral Blood Flow and Blood Volume in Neonates with the Intravoxel Incoherent Motion Method

Alex Cerjanic^1,2, Ellen Grant³, Borjan Gagoski³, Marie Drottar³, Thea Francel³, Alana Matos³, Clarissa Carruthers³, Jonathan Litt⁴, Ryan Larsen², and Bradley P Sutton^1,2

¹Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Boston Children's Hospital, Boston, MA, United States, ⁴Beth Israel Deaconness, Boston, MA, United States

Diffusion weighted MRI was used on a cohort of 5 neonates to quantify cerebral blood flow and cerebral blood volume through the intravoxel incoherent motion (IVIM) model. Data at two time points, approximately 2 weeks and 14 weeks, were obtained. The obtained pseudodiffusion coefficient and the perfusion fractions were examined across white matter, gray matter, and the basal ganglia for all subjects. A significant longitudinal decrease in the perfusion fraction (-1.12%) was noted in the white matter between 2 and 14 weeks while the static diffusion coefficient of tissue decreased for all tissue classes between those time points.

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