Abstract #1396

Dysfunction of the Cingulo-Opercular Network in First-Episode, Medication-Naive Patients with Major Depressive Disorder

xiaoping wu¹, yanjun gao¹, Pan Lin², Junle Yang¹, Rui Yang³, and Jian Yang⁴

¹Department of Radiology, the Affiliated Xi’an Central Hospital of Xi’an Jiaotong University, Xi’an, China, People's Republic of, ²Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi’an Jiaotong University, Xi’an, China, People's Republic of, ³Department of Psychiatry, the Affiliated Xi’an Central Hospital of Xi’an Jiaotong University, Xi’an, China, People's Republic of, ⁴Department of Radiology, the First Affiliated hospital of Xi’an Jiaotong University, Xi’an, China, People's Republic of

Patients with MDD showed abnormalities in the connectivity of the CON. We found abnormal connectivity in MDD patients between the dACC and the bilateral middle frontal gyrus (MFG) and between the middle temporal gyrus (MTG) and precentral gyrus. Moreover, regression analysis showed that depression symptom severity (measured with the Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Scale (HAMA) and Automatic Thoughts Questionnaire scores (ATQ)) was significantly correlated with the FC values of the CON.

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