Abstract #1379

MR based texture and location analysis of lower grade gliomas combined with genetic mutation information

Manabu Kinoshita¹, Hideyuki Arita², Mio Sakai³, Naoki Kagawa², Yonehiro Kanemura⁴, Yasunori Fujimoto², Katsuyuki Nakanishi³, and Toshiki Yoshimine²

¹Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan, ²Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan, ³Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan, ⁴National Hospital Organization Osaka National Hospital, Osaka, Japan

Extensive genetic analysis of WHO grade 2 and 3 gliomas (lower grade glioma) revealed that they comprise of several disease subtypes with different genetic or molecular backgrounds. The present investigation was conducted to elucidate the differences revealed on MR images including textures and locations of the tumors according to genetic mutation status (IDH and TERT promoter mutation) of lower grade gliomas. T2-entropy, a newly introduced image texture metric revealed that tumor heterogeneity is different depending on genetic status. Furthermore, classic oligodendroglial tumors located at the mid-base frontal lobe while astrocytic tumors occupied much lateral side of the brain.

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