Seung-Koo Lee1, Yoon Seong Choi2, Sung Soo Ahn1, Ho-Joon Lee1, and Jinna Kim1
1Seoul, Korea, Republic of, 2Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of
We
investigated the difference in APT values according to histopathological
grades, and compared the diagnostic value of APT with relative cerebral blood
volume (rCBV) from dynamic susceptibility contrast-enhanced (DSC) MRI and
apparent diffusion coefficient (ADC) from diffusion weighted imaging (DWI) for
histopathological grades in adult diffuse gliomas. We optimized APT imaging
protocol for clinical setting and found that APT values were increased along
with glioma grades, and APT values has incremental values over ADC values for
glioma grading. We suggest that APT imaging can be a useful noninvasive imaging
biomarker for glioma grading, in combination with ADC.
