Daniel M Fountain1, Timothy J Larkin2, Natalie R Boonzaier2, Jiun-Lin Yan2, and Stephen J Price2
1The Brain Tumour Imaging Laboratory, Division of Neurosurgery, University of Cambridge, Cambridge, United Kingdom, 2Division of Neurosurgery and Wolfson Brain Imaging Centre, The Brain Tumour Imaging Laboratory, Cambridge, United Kingdom
IDH-1 mutated glioblastoma is associated with improved
survival, and greater sensitivity to further resection of non-enhancing disease
than IDH-1 wild-type. We used structural, diffusion tensor, perfusion and
spectroscopic imaging data in a mixed model across the peritumoral region in 54
patients. Applying a mixed model methodology across three levels of data
resolution, we demonstrated that IDH-1 mutated tumors demonstrated raised
choline and lowered glutamate and glutamine compared to IDH-1 wild-type. The
findings provided an AUC of 0.943 when combined with age. We hypothesised this
results in greater sensitivity to treatment and reduced excitotoxicity, thus
explaining their relatively superior prognosis.
