Abstract #1360

1H Echo Planar Spectroscopic Imaging of 2-hydroxyglutarate in Gliomas at 7T in vivo

Zhongxu An¹, Sandeep Ganji¹, Vivek Tiwari¹, Marco C. Pinho^1,2, Edward Pan^3,4,5, Bruce E. Mickey^3,5,6, Elizabeth A. Maher^3,4,6,7, and Changho Choi^1,2,3

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁵Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁶Annette Strauss Center for Neuro-Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁷Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States

2-hydroxyglutarate (2HG) is the first imaging biomarker for IDH-mutated gliomas. High-spatial resolution spectroscopic imaging of 2HG is clinically important. We propose a new EPSI read-out scheme to overcome the conventional limitation of EPSI spectral bandwidth at high field. With SNR and linewidth benefit at 7T, we demonstrated the in vivo feasibility of this new EPSI method in mapping of 2HG and other important brain metabolites in normal subject and glioma patients at 7T.

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