Abstract #1352

An MRS and PET guided biopsy tool for ultrasound-based intra-operative neuro-navigational systems.

Matthew Grech-Sollars^1,2, Babar Vaqas³, Gerard Thompson⁴, Tara Barwick^2,5, Lesley Honeyfield², Kevin S O'Neill³, and Adam D Waldman^1,2

¹Division of Brain Sciences, Imperial College London, London, United Kingdom, ²Department of Imaging, Imperial College NHS Healthcare Trust, London, United Kingdom, ³Department of Neurosurgery, Imperial College NHS Healthcare Trust, London, United Kingdom, ⁴Department of Neuroradiology, Salford Royal NHS Foundation Trust, Salford, United Kingdom, ⁵Department of Surgery and Cancer, Imperial College London, London, United Kingdom

Glioma heterogeneity and the limitations of conventional structural MRI to identify agrressive tumour components limits targeting of stereotactic biopsy, and hence tumour characterisation. In vivo MR spectroscopy and PET allow for physiological characterisation of tumour and we here present a method for representing MRS and PET defined regions to biopsy using an ultrasound based neuronavigational system. Our method involves using colour-coded hollow spheres to represent the target biopsy regions, which can be easily identified during the surgery. This approach can be applied to target the most aggressive regions of a tumour and as a tool for imaging biomarker validation.

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