Investigation of hypoxia conditions using oxygenation enhance (OE)-MRI measurements in C6 glioma models
Yingwei Wu1, Yongming Dai2, Qi Fan1, and Xianfeng Tao1
1Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, People's Republic of, 2Philips Healthcare, Shanghai, China, People's Republic of
We used oxygenation enhancement (OE)-MRI measurements to investigate hypoxia conditions of gliomas and to evaluate relationship between histopathology measurements and PSC. Oxygen amplitude maps of C6 glioma models were derived. ROI max and ROI non-max were defined. Time-SI curve from ROI areas was obtained and tissues from ROI areas was evaluated for microvessel density and expression of HIF-1a. We found that microvessel density in ROI non-max area were lower than those in ROI max area and expression of HIF-1α in ROI non-max area were higher than that in ROI max area. PSC had a linear positive correlation with vessel density.
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