Relationships between intratumoral heterogeneity parameters using diffusion, perfusion MRI, and FDG PET in head and neck cancer
Su Jin Lee1, Jin Wook Choi2, and Miran Han2
1Nuclear Medicine, Ajou University School of Medicine, Suwon, Korea, Republic of, 2Radiology, Ajou University School of Medicine, Suwon, Korea, Republic of
MRI and PET can provide tumor biology information
noninvasively. ADC from DWI can represent cellularity, DCE-MRI can provide
microcirculation, and FDG PET can provide tumor metabolism. Intratumoral
heterogeneity is often associated with adverse tumor biology and it can be
assessed by these imaging parameters. Tumor heterogeneity on DWI can be simply evaluated
by the difference between minimum and maximum ADC value. Metabolism to
perfusion ratio can be calculated using DCE-MRI and FDG PET. Texture analysis
of PET can be used to evaluate tumor heterogeneity. Thus we investigated the
relationships between intraheterogeneity parameters derived from multimodality
imaging.
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