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Abstract #1318

Longitudinal characterization of the Theiler's Murine Encephalomyelitis Virus (TMEV) mouse model using a cryogenic brain coil at 9.4T

Nicola Bertolino1, Claire M Modica1,2, Michael G Dwyer1, Paul Polak1, Trina Ruda1, Marilena Preda1,3, Jacqueline C Krawiecki1,4, John M Barbieri1,5, Michelle L Sudyn1,2, Danielle M Siebert1,6, Robert Zivadinov1,3, and Ferdinand Schweser1,3

1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, 2Neuroscience Program, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, 3MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, 4Department of Geology, The State University of New York at Buffalo, Buffalo, NY, United States, 5Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, 6Department of Exercise and Nutritional Sciences, School of Public Health and Health Professions, The State University of New York at Buffalo, Buffalo, NY, United States

Theiler's Murine Encephalomyelitis Virus (TMEV) infection is a mouse model of multiple sclerosis (MS) with a similar disease course to human MS. In susceptible breeds TMEV infections gives way to a progressive demyelinating course and a chronic, immune-mediated, demyelinating, neurodenegerative condition that persists for the remainder of the natural life of the animal.

While post mortem tissue and motor disability are well-characterized in TMEV, structural and metabolite tissue damage associations are not thoroughly understood. In this work, we studied the TMEV model over 2 months after the infection using advanced MRI with a cryogenic brain coil at 9.4 Tesla.

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