Spatial and temporal characterization of blood brain barrier permeability with disease progression in the NOD-EAE mouse model using MRI and histology
Mohammed Salman Shazeeb1, Nellwyn Hagan2, Xiaoyou Ying1, and Andrea Edling2
1DSAR Bioimaging, Sanofi, Framingham, MA, United States, 2Neuroimmunology, Sanofi, Framingham, MA, United States
Blood
brain barrier (BBB) dysregulation is one of the earliest signs of multiple sclerosis
(MS) and the mechanism underlying BBB breakdown in not completely understood. The
non-obese diabetic experimental allergic encephalomyelitis (NOD-EAE) mouse
model of secondary progressive MS offers a preclinical tool to understand BBB
breakdown and explore potential therapeutics. MRI is capable of quantifying BBB
permeability using gadolinium contrast agent. In this study we quantified the
spatial and temporal characterization of BBB permeability in NOD-EAE mice with
progressing disease using MRI. These quantifying parameters can potentially be
used to test the effect of therapeutic agents on BBB breakdown.
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