Abstract #1308

Functional response to a complex visuo-motor task supports local compensatory mechanisms in Multiple Sclerosis

Adnan A.S. Alahmadi^1,2, Matteo Pardini^1,3, Rosa Cortese¹, Niamh Cawley¹, Rebecca S. Samson¹, Egidio D'Angelo^4,5, Karl J. Friston⁶, Ahmed T. Toosy^1,7, and Claudia Angela Michela Gandini Wheeler-Kingshott^1,5

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, ²Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, ³Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy, ⁴Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ⁵Brain Connectivity Center, C.Mondino National Neurological Institute, Pavia, Italy, Pavia, Italy, ⁶Wellcome Centre for Imaging Neuroscience, UCL, Institute of Neurology, London, United Kingdom, ⁷NMR Research Unit, Department of Brain Repair and Rehabilitation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom

We investigated simple and complex (non-linear) relationships between BOLD signals and different applied grip forces in multiple sclerosis (MS) patients and healthy volunteers (HV). Using a power grip event-related paradigm and modelling BOLD responses with a polynomial expansion of force, we show profound and distributed functional network reorganizations in sensorimotor, associative and cerebellar areas, probably indicating compensatory mechanisms in MS.

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