Abstract #1303

Regional analysis of diffusion MRI (DKI/DTI) in patients with multiple sclerosis: Correlation with cognitive function and clinical measures

Phil Lee^1,2, Peter Adany¹, Douglas R. Denney³, Abbey J. Hughes³, Sharon G. Lynch⁴, and In-Young Choi^1,2,4

¹Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, ²Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States, ³Psychology, University of Kansas, Lawrence, KS, United States, ⁴Neurology, University of Kansas Medical Center, Kansas City, KS, United States

Diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) techniques were used to evaluate microstructure changes multiple brain regions as well as gray and white matter in patients with multiple sclerosis at various disease stages and types. DKI/DTI parameters in various brain regions were able to distinguish MS subtypes, and to discriminate patients from controls. Microstructure alterations measured by DKI/DTI were region-specific and correlated with cognitive function and clinical status of patients, providing promising metrics in clinical applications to assess disease status and progression.

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