Abstract #1299

Cerebellar contribution to motor and cognitive impairment in multiple sclerosis patients: a sub-regional structural MRI analysis

Elisabetta Pagani¹, Maria Assunta Rocca^1,2, Alessandro D'Ambrosio^1,3, Gianna Carla Riccitelli¹, Bruno Colombo², Mariaemma Rodegher², Andrea Falini⁴, Giancarlo Comi², and Massimo Filippi^1,2

¹Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ³I Division of Neurology, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy, ⁴Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

Aim of the study was to assess the role of cerebellar global and sub-regional involvement on motor and cognitive impairment in multiple sclerosis (MS) patients. Cerebellar segmentation and lobular parcellation was performed on T1 weighted images from 95 MS patients and 32 healthy controls using SUIT tool. The Nine Hole Peg Test was obtained as a measure of motor performance; patients also underwent cognitive evaluation. Cerebellar posterior-inferior volume accounted for variance in cognitive measures in MS patients, whereas anterior cerebellar volume accounted for variance in motor performance, supporting a critical contribution of regional cerebellar damage to clinical manifestations of MS.

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