Assessment of whole brain blood flow changes in multiple sclerosis: phase contrast MRI versus ASL
Yulin Ge1, Olga Marshall1, Ilya Kister1, Jean-Christophe Brisset1, Louise Pape1, Jacqueline Smith1, and Robert I Grossman1
1Radiology, New York University School of Medicine, New York City, NY, United States
Cerebral
blood flow (CBF) is an important characteristic of the brain since it reflects
the availability of blood to enable healthy neuronal function. Previous studies
in multiple sclerosis (MS) have shown regional hemodynamic changes indicating a
state of both increased or decreased perfusion, which may reflect underlying
neuroinflammatory activity and impaired vascular perfusion of the disease,
respectively. However, it is still unclear how the whole brain blood supply or
blood flow changes in MS. This study was to investigate whether global CBF
levels are effected in MS compared to controls, while evaluating with two
different imaging techniques to confirm the findings.
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