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Abstract #1285

RAFF4 MRI in detection of demyelinating lesions induced by lysophosphatidyl choline injections in rat

Lauri J Lehto1,2, Alejandra Sierra1, Aloma Albors1, Shalom Michaeli2, Antti Nurmi3, Laura Tolppanen3, Lynn E Eberly4, Silvia Mangia2, and Olli Gröhn1,2

1A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Charles River Laboratories, Kuopio, Finland, 4Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States

An MRI contrast sensitive to demyelination would be invaluable in assessing a multitude of neurodegenerative diseases. Here, we demonstrate the benefits of a novel rotating frame method entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn) in detection of demyelinating lesions induced by lysophosphatidyl choline (LPC) injections in the rat corpus callosum (CC) and dorsal tegmental tract (DTG). RAFFn performed better than magnetization transfer in CC and DTG, and clearly outperformed diffusion tensor imaging in DTG, an area with heterogeneous fiber orientation distribution. Our results demonstrate high potential of RAFFn for imaging demyelinating lesions.

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