Abstract #1282

Longitudinal Observation of Individual Multiple Sclerosis White Matter Lesions Using Quantitative Myelin Imaging

Hagen H Kitzler¹, Köhler Caroline¹, Wahl Hannes¹, Eisele C Judith², Sean C Deoni³, Brian K Rutt⁴, Tjalf Ziemssen², and Jennifer Linn¹

¹Neuroradiology, Technische Universität Dresden, Dresden, Germany, ²Neurology, Technische Universität Dresden, Dresden, Germany, ³Children's Hospital, Colorado, University of Colorado Medical School, Denver, CO, United States, ⁴Radiology, Stanford University, Stanford, CA, United States

Myelin Imaging is a potential tool to study demyelination and remyelination in inflammatory central nervous system diseases. This work presents a specific approach of tracking the individual myelination in single Multiple Sclerosis lesions and their pattern in Clinically Isolated Syndrome and early MS. Within n = 137 lesions of n = 15 patients we found 25% constant myelin loss, 14% permanent myelin regain, 56% fluctuating myelin content, and, 5% stable myelin reduction. These findings demonstrate an in vivo measurable highly dynamic individual lesion myelination status in inflammatory early disease. This method may facilitate to observe damage and reparative mechanism distribution in individual patients.

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