Dushyant Kumar1,2, Patrick Borchert1, Jens Fiehler1, Susanne Siemonsen1,2, and Jan Sedlacik1
1Dept. of Diagnostic and Interventional Radiology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 2Institute of Neuroimmunology and Multiple Sclerosis, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
Problem: The clinical utility of myelin
imaging based on “gold standard” multi echo spin echo (MESE) T2 relaxometry is
currently impeded due to requirement of high SNR and need to account for contributions
from stimulated pathways. We compare faster GRASE based myelin quantification against those
from MESE.
Methods:
3D
non-selective GRASE and MESE were optimized. Implemented post processing method
combines T2-decay model based extended phase graph with spatial regularization
framework to improve on noise robustness and accurately account for B1-error.
Results & Conclusions:
Results
demonstrate good consistency between MWF-maps from both sequences, except in left part of
frontal brain.
