Carles Falcon1,2, Alan Tucholka1, Juan Domingo Gispert1,2, Gemma Cristina Monte-Rubio3, Lorena Rami3,4, and Jose Luis Molinuevo3,4
1BarcelonaBeta Brain Research Center. Pasqual Maragall Foundation, Barcelona, Spain, 2CIBER-BBN, Barcelona, Spain, 3Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 4Neurology, Hospital Clinic of Barcelona, Barcelona, Spain
We report the correlation of two-year gray matter (GM) changes with basal levels
of Aβ42, p-tau and p-tau/Aβ42 in CSF on a sample of 62 cognitively normal subjects (18 Aβ42
positive and 26 p-tau positive),
aged 60-80. GM volume decrease was correlated with Aβ42 in medial and orbital frontal, precuneus,
cingulate, medial temporal regions and cerebellum. Correlations with
p-tau were located in left hippocampus, parahippocampus and striatal nuclei and
with p-tau/Aβ42 in ventral and medial temporal areas. We conclude
that diverse pathological mechanisms in the preclinical stage could underpin atrophy
rates in different regions known to be altered in AD
