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Abstract #1229

Comparison of Thalamic GABA and Glx Levels in Patients with Essential Tremor and Parkinson's Disease

Ruoyun Ma1,2, Johnathan P Dyke3, Shalmali Dharmadhikari4, Nora Hernandez5, Elizabath Zauber6, Elan Louis5,7,8, and Ulrike Dydak1,2

1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 3Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 4Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, 5Department of Neurology, Yale School of Medicine, New Heaven, CT, United States, 6Department of Neurology, Indianapolis University School of Medicine, Indianapolis, IN, United States, 7Department of Chronic Disease Epidemiology, Yale School of Public Health, New Heaven, CT, United States, 8Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, New Heaven, CT, United States

Essential tremor (ET) and Parkinson’s disease (PD) are two most prevalent movement disorders. It was suggested that tremors in both diseases, though of different types, may be modulated by neuropathways involving the thalamus. We found a significant trend of elevated thalamic GABA levels from controls to ET patients to PD patients, which may be related to the increased risk of ET patients to develop PD, and thus suggesting thalamic GABA as imaging marker of preclinical parkinsonism. However, thalamic GABA is not associated with tremor of either type.

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Abstract