Sushanta Kumar Mishra1,2, Subash Khushu1, and Gurudutta Gangenahalli2
1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India, 2Division of Stem Cell and Gene Therapy Research, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Mesenchymal stem cells have been shown to be
effective against neuronal degeneration through mechanisms that include both
the recovery of neurometabolites and behavioural activity. This study
demonstrates that intravenous administration of MSCs in traumatic brain injury
mice alter the neurometabolic concentration at lesion site and improve the behavioural
functional outcome. The concentrations of metabolites like phosphocholine and
inositol were increased, while other metabolites like NAA, GABA, Cr+PCr,
Glu+Gln and taurine were decreased at injury site after MSCs transplantation
and become its normal concentrations. The functional activities like stress
level, grip strength and depression index were improved in transplanted TBI
mice.
