Marco Pagani1,2, Angelo Bifone1, and Alessandro Gozzi1
Structural covariance MRI
(scMRI) has highlighted robust gray matter networks encompassing known
neuroanatomical systems of the human brain. The application of scMRI in the
mouse can provide insights on the elusive neurobiological determinants
underlying the emergence of this phenomenon. We show that the mouse brain
contains robust inter-hemispheric anatomical covariance networks
recapitulating anatomical features observed in humans. Our findings pave the
way to the use of mouse genetics to investigate the biological underpinnings of
scMRI networks and their aberration in brain disorders.
