Abstract #1200

Tractography Study of Brain Asymmetries in a Genetic Mouse Model

Alexandra Petiet^1,2, Gonçalo C Vilhais-Neto^3,4, Daniel Garcia-Lorenzo¹, Stéphane Lehéricy^1,2, and Olivier Pourquié^3,4,5,6,7

¹Center for Neuroimaging Research, Brain and Spine Institute, Paris, France, ²UPMC/Inserm UMRS1127 / CNRS UMR7225, Paris, France, ³Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, ⁴Stowers Institute for Medical Research, Kansas City, MO, United States, ⁵Howard Hughes Medical Institute, Kansas City, MO, United States, ⁶Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, MO, United States, ⁷Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Woman’s Hospital, Boston, MA, United States

While humans show clear preference for right hand usage (90%), normal mice show consistent right or left paw usage (50%). We used a Rere-deficient mouse model (Rere^+/om) that shows clear right paw usage preference (80%) compared to wild-type (WT) mice (40%) to evaluate structural connectivity changes in the cortico-spinal tract (CST) using diffusion-based tractography. Our results showed significantly reduced and more asymmetric FA along the CST of the dominant hemisphere in the dextral mutant group compared to the WT group. These results show Rere-dependent structural connectivity changes in the brain that could be clinically relevant to human pathologies.

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