Abstract #1190

A Diffusional Kurtosis Imaging Study of the White Matter Abnormalities in Type-2 Diabetic Brain

YING XIONG^1,2, Shun Zhang¹, Qiang Zhang³, and Wenzhen Zhu¹

¹Radiology Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, People's Republic of, ²Certer for MR Research, University of Illinois at Chicago, Chicago, IL, United States, ³Neurology Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, People's Republic of

This study aims at investigating brain microstructural changes in white-matter (WM) of type 2 diabetes mellitus (T2DM) patients using diffusional kurtosis imaging (DKI), and making a comparison with diffusion tensor metrics. Thirty T2DM patients and 28 health controls were recruited and imaged on a 3 Tesla scanner. It was found that in the whole-brain and atlas-based analysis, mean kurtosis (MK) detected more regions with WM alterations than fractional anisotropy (FA), especially in some regions including crossing fibers. DKI can complement conventional DTI and provide more information to characterize and pinpoint brain microstructural changes in WM of T2DM patients.

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