Abstract #1167

Evaluation of 3D T1-weighted imaging at 3 T across scanner vendors and models

Sjoerd B Vos^1,2, M Jorge Cardoso¹, Marzena Wylezinska-Arridge³, David L Thomas^1,3, Enrico De Vita^3,4, Marios C Yiannakas⁵, David Carmichael⁶, John S Thornton^3,4, Olga Ciccarelli⁵, John S Duncan^2,7, and Sebastien Ourselin¹

¹Translational Imaging Group, University College London, London, United Kingdom, ²MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom, ³Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, ⁴Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁵Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, ⁶Institute of Child Health, University College London, London, United Kingdom, ⁷Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom

Volumetric analyses of 3D T1-weighted images has become an integral part of the clinical work-up and research studies. Variation between scanners, in both vendors and models, is a major confound in combining imaging-derived biomarkers across sites. In this work, we analyse test-retest data from different days on six 3 T scanners from three vendors to quantify this inter-scanner variability compared to intra-scanner variability. Contrast-to-noise ratios as well as volumetric analyses are performed showing between-scanner variation in total brain volumes – indicating different scanner calibrations – but also tissue-specific differences – possibly arising from different effective contrasts.

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