Abstract #1142

CEST Imaging Targeted APT vs. FDG-PET/CT: Capability for Differentiating Malignant from Benign Pulmonary Lesions

Yoshiharu Ohno^1,2, Masao Yui³, Mitsue Miyazaki⁴, Yuji Kishida², Shinichiro Seki², Hisanobu Koyama², Katsusuke Kyotani⁵, Takeshi Yoshikawa^1,2, and Kazuro Sugimura²

¹Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan, ²Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Toshiba Medical Systems Corporation, Otawara, Japan, ⁴Toshiba Medical Research Institute USA, Vernon Hills, IL, United States, ⁵Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Japan

Chemical exchange saturation transfer (CEST) imaging is suggested as a new technique for MR-based molecular imaging techniques in vivo and in vitro studies. We hypothesized that newly developed CEST imaging, may have a similar potential for differentiating malignant from benign pulmonary nodules and masses, when compared with FDG-PET/CT. The purpose of this study was to directly and prospectively compare the capability of CEST imaging targeted to amide groups (-NH) for differentiation of malignant from benign pulmonary lesions with FDG-PET/CT.

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