Abstract #1136

In-vivo Characterization of Human Lumbar Intervertebral Discs by Magnetic Resonance Elastography: Diurnal Changes in Shear Stiffness and Relationship with Degeneration

Benjamin A Walter^1,2, Prasath Mageswaran^1,3, Hazem Mashaly^1,4, William Thoman ^1,4, Daniel Boulter⁵, Luciano Prevedello ⁵, Xuan Nguyen ⁵, Mo Xiaokui ⁶, Ehud Mendel ^1,4, William Marras^1,3, and Arunark Kolipaka^1,2,5,7

¹Spine Research Institute, The Ohio State University, Columbus, OH, United States, ²Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ³Integrated Systems Engineering, The Ohio State University, Columbus, OH, United States, ⁴Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ⁵Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ⁶Biomedical Informatics, The Ohio State University, Columbus, OH, United States, ⁷Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States

Magnetic resonance elastography (MRE) was used to assess intervertebral disc (IVD) shear properties in order to develop an objective biomarker for the IVD degeneration process. This study characterized the frequency response and repeatability of MRE assessment of IVD shear stiffness and how the shear stiffness of the nucleus pulposus (NP) region of the IVD changes during degeneration. Results suggest that MRE derived NP shear stiffness is a repeatable technique that can provide a relative and objective measurement of IVD degeneration that is independent of age.

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