Abstract #1113

In Vivo Detection of Short T2* Lipid 1H in Mouse Brain with a ZTE/UTE Subtraction Method (ZUS)

Yaotang Wu^1,2, Michael Marcotrigiano³, Hui Xue^1,2,4, Robert V Mulkern^1,2, and Jeffrey Neil^2,5

¹Department of Radiology, Boston Children's Hospital, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Department of Research, Boston Children's Hospital, Boston, MA, United States, ⁴Sichuan University, Chengdu, China, People's Republic of, ⁵Department of Neurology, Boston Children's Hospital, Boston, MA, United States

A new method, ZUS, utilizes ZTE to detect all signals with T2* as short as a few hundred microseconds, including myelin proton signals, and UTE to selectively detect signals with longer T2* values, considered to be tissue water components. The difference of these two types of images is used to visualize signals from lipid 1H. In this study, the feasibility of ZUS was demonstrated on a cholesterol phantom (the major component of myelin) and on a live mouse. ZUS images highlighted lipid, particularly myelin in the corpus callosum, of mouse brain in vivo.

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